Haemophagocytic Lymphohistiocytosis with Lung Cavity and Lytic Bone Lesion in A 45 Day Infant
Published: March 1, 2014 | DOI: https://doi.org/10.7860/JCDR/2014/.4145
Sanjay A Natu, Ujjwala S Keskar, Manas K Behera , Sambhaji C Chate
1. Associate Professor, Department of Paediatrics, Smt Kashibai Navale Medical College, Pune, India.
2. Associate Professor, Department of Paediatrics, Smt Kashibai Navale Medical College, Pune, India.
3. Professor, Department of Paediatrics, Smt Kashibai Navale Medical College, Pune, India.
4. Assistant Professor, Department of Paediatrics, Smt Kashibai Navale Medical College, Pune, India.
Correspondence
Dr. Sanjay Natu,
Flat No -20, Sarthak Terrace, 18/1 Kothrud, Pune-411029, India.
Phone: 9822639522, E-mail: sanjaynatu@gmail.com
Haemophagocytic lymphohistiocytosis (HLH) is a potentially fatal, hyper inflammatory condition which is caused by a highly stimulated but ineffective immune response. We are presenting here, a case of HLH which occurred in a 45 day infant. Presence of lung cavity and a lytic bone lesion in the skull, as was seen in this case, have not been reported in HLH in the literature. This raises a possibility of a simultaneous occurrence of HLH and Langerhans cell histiocytosis. In a child who presents with septicaemia but does not respond to treatment, the possibility of HLH needs to be considered.
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